Aurintricarboxylic Acid Ameliorates

Canine Model of Coronary Artery Thrombosis

Platelet thrombus formation occurs at sites of severe arterial narrowing where shear stress is elevated. Shear stress appears to induce platelet aggregation in vitro by means of initiation of von Willebrand factor binding to platelet glycoprotein lb. Recent in vitro studies have demonstrated that aurintricarboxylic acid can inhibit shear stress-induced platelet aggregation. This effect is media...

Method for Inhibiting Angiogenesis with Aurintricarboxylic Acid, Its Analogues or Salts

Release of the nonribosomal proteins from the mammalian native 40 S ribosomal subunit by aurintricarboxylic acid.

Selection of an effective red-pigment producing Monascus pilosus by efficient transformation with aurintricarboxylic acid.

The filamentous fungus Monascus pilosus was genetically transformed with a reporter plasmid, pMS-1.5hp, by aurintricarboxylic acid (ATA) treatment to obtain an efficient red-pigment producing mutant. The transformation efficiency of Monascus pilosus was higher with the ATA-treatment than with either a non-restriction-enzyme-mediated integration (REMI) or a REMI method. This valid and convenient...

Aurintricarboxylic acid: inhibitor of initiation of protein synthesis.

Aurintricarboxylic acid prevents the attachment of bacteriophage messenger RNA to ribosomes. As a consequence, initiation of protein synthesis in cell-free extracts prepared from Escherichia coli or rabbit reticulocytes is inhibited at concentrations of dye that do not prevent chain extension. Its properties can be distinguished from other agents that inhibit protein synthesis, including sodium...